Looking to get Dean out of the bunker, Sam finds a case for him and Dean to investigate – people are disappearing into thin air with only their clothes left…

Sam and Dean track down the missing Crowley and discover that he’s now thoroughly addicted to human blood. Once they get him sober, the brothers go seeking the First Blade…

Sam and Dean are stunned when a man who claims to be Henry Winchester, their grandfather, suddenly appears in their hotel room demanding to know where he can find John…