Willoughby Kipling conscripts the Doom Patrol into helping him avert the end of the world by stopping a nihilistic cult.

The Doom Patrol set out for Paraguay where they discover the Nazi doctor who created Mr. Nobody and the connection between The Chief and the two villains.

Following Mr. Nobody’s capture of The Chief, the Doom Patrol investigate the mysterious albino donkey and discover it’s a door to another universe, where Mr. Nobody is in control.

The reluctant heroes of the Doom Patrol – Robotman, Negative Man, Elasti-Woman and Crazy Jane face the threat of Mr. Nobody, who’s after The Chief.